Investigation of the effects of mesenchymal stem cell administration on liver recovery in experimental hepatotoxicity model

Hepatotoxicity refers to liver dysfunction associated with certain medical drugs and chemicals. Studies have shown that mesenchymal stem cells a positive effect on the improvement of diseases. The aim this study was investigate potential protective effects fetal kidney-induced Doxorubicin-induced hepatotoxicity in rats. Sprague dawley rats were divided into three groups as control, sham, treatment group. Intraperitoneal treated BrdU prior transplantation so they could be followed up after invivo transplantation. After completion experimental steps, monitored for 5 weeks. Then terminated their livers taken histopathological immunohistochemical evaluation. In examinations performed TNF-α, Caspase-3 COX-2 primary antibodies, most severe positivity sham group, by control groups. While found statistically similar staining anti-BrdU antibody, group significantly different from other (p<0.05). As result, it has been revealed administered intraperitoneally hepatotoxicity, prevent degeneration necrosis hepatocytes, COX-2, levels decreased immunohistochemically, proving increased regeneration.